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Compound InformationSONAR Target prediction
Name:

Colchicine

Unique Identifier:LOPAC 00810
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C22H25NO6
Molecular Weight:374.239 g/mol
X log p:9.286  (online calculus)
Lipinksi Failures1
TPSA71.06
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:7
Rotatable Bond Count:6
Canonical Smiles:COC1=CC=C2C(=CC1=O)C(CCc1cc(OC)c(OC)c(OC)c12)NC(C)=O
Class:Cytoskeleton and ECM
Action:Inhibitor
Selectivity:Tubulin

Found: 24 nonactive as graph: single | with analogs 1 2 3 4 5 6 7 8 9 10  Next >> [24]
Species: 4932
Condition: BY4741
Replicates: 8
Raw OD Value: r im 0.7486±0.0979455
Normalized OD Score: sc h 1.0008±0.0209413
Z-Score: 0.0410±0.668178
p-Value: 0.687364
Z-Factor: -12.1999
Fitness Defect: 0.3749
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Lopac
Plate Number and Position:4|G11
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:27.60 Celcius
Date:2005-04-07 YYYY-MM-DD
Plate CH Control (+):0.04620624999999999±0.00241
Plate DMSO Control (-):0.7474874999999999±0.05282
Plate Z-Factor:0.8689
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DBLink | Rows returned: 71 2 Next >> 
2833
6167
23758
53278
450692
537229

internal high similarity DBLink | Rows returned: 3
SPE01800067 0.9440
BTB 12749 1.0000
SPE01500205 1.0000

active | Cluster 2172 | Additional Members: 11 | Rows returned: 3
Prest353 0.493506493506494
Prest875 0.386363636363636
SPE01800067 0.217391304347826

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